Journal: BMC Bioinformatics

Article Title: Neural representations of cryo-EM maps and a graph-based interpretation

doi: 10.1186/s12859-022-04942-1

Figure Lengend Snippet: a A threshold high enough to distinguish separate clusters of voxels is too high for many side chain atoms and atoms on the periphery of the protein structure (orange), demonstrated using EMD-11103. The dark gray voxel data is not uniformly representative of all atoms given a high-pass filter value, which illustrates the need for a better representation of the map. b Localized view of graph nodes (blue) created by our method for the atomic resolution map EMD-11103 human apoferritin (transparent gray) and the atom locations of the corresponding deposited structure PDB-6z6u (orange)

Article Snippet: The dark gray voxel data is not uniformly representative of all atoms given a high-pass filter value, which illustrates the need for a better representation of the map. b Localized view of graph nodes (blue) created by our method for the atomic resolution map EMD-11103 human apoferritin (transparent gray) and the atom locations of the corresponding deposited structure PDB-6z6u (orange) In this paper, we present a novel data format for high-resolution cryo-EM maps that can produce a fully continuous, non-linear interpolation of the EM data using neural network representation.

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